Zhanxiang Liu

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Name: 刘占祥; Liu, ZhanXiang

Organization: Zhejiang University , China

Department: Department of Chemistry

Title: Associate Professor(PhD)

Chemicals
References

Synthesis of Benzyl Esters via Functionalization of Multiple C–H Bonds by Palladium Catalysis

Co-reporter:Danyang Li, Ming Yu, Jitan Zhang, Zhanxiang Liu, and Yuhong Zhang

Organic Letters 2015 Volume 17(Issue 21) pp:5300-5303

Publication Date(Web):October 13, 2015

DOI:10.1021/acs.orglett.5b02518

A highly efficient, selective synthesis of benzyl esters by palladium catalysis is developed through the bidentate directing group assisted functionalization of multiple C(sp3)–H bonds.

Nickel-Catalyzed Direct Amination of Arenes with Alkylamines

Co-reporter:Qiangqiang Yan, Zhengkai Chen, Wenlong Yu, Hong Yin, Zhanxiang Liu, and Yuhong Zhang

Organic Letters 2015 Volume 17(Issue 10) pp:2482-2485

Publication Date(Web):May 5, 2015

DOI:10.1021/acs.orglett.5b00990

The efficient nickel-catalyzed direct amination of arenes with simple alkylamines has been achieved with the assistance of a bidentate directing group through sp2 C–H bond functionalization. Preliminary mechanistic investigations indicate that the reaction probably proceeds through a NiI/NiIII catalytic pathway.

Efficient Synthesis of cis-3-Substituted Prolines by Bidentate-Assisted Palladium Catalysis

Co-reporter:Ruokun Feng;Binjie Wang;Yue Liu;Yuhong Zhang

European Journal of Organic Chemistry 2015 Volume 2015( Issue 1) pp:142-151

Publication Date(Web):

DOI:10.1002/ejoc.201403191

Abstract

A highly effective protocol for the synthesis of C-3-substituted prolines has been developed. Pd-catalyzed C(sp³)–H activation is used for the straightforward functionalization of prolines. The use of an 8-aminoquinolinecarboxamide directing group allows direct arylation, alkenylation, and alkylation at the C-3 position of prolines in moderate to high yields with diverse iodo- or bromo precursors. The resulting 3-substituted proline derivatives are important units in many biologically active compounds and are useful promoters for a variety of functional group transformations.

Ester-Directed Selective Olefination of Acrylates by Rhodium Catalysis

Co-reporter:Ruokun Feng;Wenlong Yu;Kai Wang;Yuhong Zhang

Advanced Synthesis & Catalysis 2014 Volume 356( Issue 7) pp:1501-1508

Publication Date(Web):

DOI:10.1002/adsc.201300944

Synthesis of 2,3-dihydro-1H-indazoles by Rh(III)-catalyzed C–H cleavage of arylhydrazines

Co-reporter:Jinzhong Yao, Ruokun Feng, Cong Lin, Zhanxiang Liu and Yuhong Zhang

Organic & Biomolecular Chemistry 2014 vol. 12(Issue 29) pp:5469-5476

Publication Date(Web):11 Jun 2014

DOI:10.1039/C4OB00921E

A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro-1H-indazoles is described. The reaction of arylhydrazines with olefins results in the corresponding 2,3-dihydro 1H-indazoles with exclusive regioselectivity via C–H bond activation. The utility of the methodology is illustrated by a rapid synthesis of 1H-indazoles under mild reaction conditions in half an hour.

A simple BODIPY–imidazole-based probe for the colorimetric and fluorescent sensing of Cu(II) and Hg(II)

Co-reporter:Rongjian Xie, Yunrui Yi, Yuan He, Xingang Liu, Zhan-Xiang Liu

Tetrahedron 2013 69(40) pp: 8541-8546

Publication Date(Web):

DOI:10.1016/j.tet.2013.07.059

Cu(II)-Promoted Palladium-Catalyzed C–H Ortho-Arylation of N,N-Dimethylbenzylamines

Co-reporter:Ruokun Feng, Jinzhong Yao, Zunjun Liang, Zhanxiang Liu, and Yuhong Zhang

The Journal of Organic Chemistry 2013 Volume 78(Issue 8) pp:3688-3696

Publication Date(Web):March 19, 2013

DOI:10.1021/jo400186p

A novel protocol for palladium-catalyzed arylation of the C(sp2)–H bond directed by a N,N-dimethylaminomethyl group in the presence of AgOAc and Cu(OAc)2·H2O is described. Various aryl iodides proved to be efficient coupling partners, furnishing the corresponding ortho monoarylated or diarylated arenes in moderate to good yields. Cu(OAc)2·H2O is found to be the important additive to improve the yields in this transformation.

Palladium-Catalyzed Oxidative Acetoxylation of Benzylic C–H Bond Using Bidentate Auxiliary

Co-reporter:Long Ju ; Jinzhong Yao ; Zaihong Wu ; Zhanxiang Liu ;Yuhong Zhang

The Journal of Organic Chemistry () pp:

Publication Date(Web):October 9, 2013

DOI:10.1021/jo401830k

Pd(OAc)2-catalyzed oxidative acetoxylation of benzylic C–H bonds utilizing a bidentate system has been explored. A variety of picolinoyl- or quinoline-2-carbonyl-protected toluidine derivatives react with PhI(OAc)2 in the presence of Pd(OAc)2 to afford the acetoxylated products in synthetically useful yields. A broad of functionalities, such as CH3, F, Cl, Br, I, COCH3, CO2Et, SO2CH3, and NO2, were tolerated. This transformation provides easy access to 2-hydroxymethylaniline derivatives.

Synthesis of 2,3-dihydro-1H-indazoles by Rh(III)-catalyzed C–H cleavage of arylhydrazines

Co-reporter:Jinzhong Yao, Ruokun Feng, Cong Lin, Zhanxiang Liu and Yuhong Zhang

Organic & Biomolecular Chemistry 2014 - vol. 12(Issue 29) pp:NaN5476-5476

Publication Date(Web):2014/06/11

DOI:10.1039/C4OB00921E