Co-reporter: Fangrui Zhong, Youqing Wang, Xiaoyu Han, Kuo-Wei Huang, and Yixin Lu
pp: 1310-1313
Publication Date(Web):February 18, 2011
DOI: 10.1021/ol103145g
A series of novel bifunctional phosphine−sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita−Baylis−Hillman (MBH) reactions. l-Threonine-derived phosphine−sulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities.
